Research Interests of the Bopp Laboratory
The major focus of research in the laboratory is the regulation of T cell responses in a context- and tissue-specific manner. Here, we particularly focus on the functional and molecular characterization of CD4+FOXP3+ regulatory T (TREG) cell and CD4+ T Helper (TH) cell differentiation and function and on non-classical ways of communication between non-hematopoietic cells and cells of myeloid and lymphoid origin. We are aiming to elucidate the role of transcription factors and transcription factor complexes in the differentiation and tissue-specific function of TREG and TH cell subsets in cancer, allergy and autoimmune disease, the role of cyclic AMP-mediated signaling in the regulation of auto-reactive T cell responses, and the role of the kinase CK2 in regulating tissue- and context-specific responses of TH cells and TREG cells.
Contact
Univ.-Prof. Dr. rer. nat. Tobias Boppbopplab@
Phone: +49 (0)
Univ.-Prof. Dr. rer. nat. Tobias Bopp
Klaus T, Wilson AS, Vicari E, Hadaschik E, Klein M, Helbich SS, Kamenjarin N, Hodapp K, Schunke J, Haist M, Butsch F, Probst HC, Enk AH, Mahnke K, Waisman A, Bednarczyk M, Bros M, Bopp T, Grabbe S. Impaired regulatory T cell-dendritic cell interactions contribute to autoimmunity in leukocyte adhesion deficiency type JCI Insight. Nov 8:e, (DOI: /t). OA = Open Access →This work shows that CD18 is crucial for Treg-dendritic cell interactions to prevent autoimmunity
K. Johann, T. Bohn, F. Shahneh, N. Luther, A. Birke, H. Jaurich, M. Helm, M. Klein, V. K. Raker, T. Bopp, M. Barz, C. Becker “Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression”, Nat. Commun. 12, , (DOI: /sw). OA → This work shows that AC inhibitor micelles repress tumor progression and improve the anti-tumor immune response
L. Schaupp, S. Muth, L. Rogell, M. Kofoed-Branzk, F. Melchior, S. Lienenklaus, S. C. Ganal-Vonarburg, M. Klein, F. Guendel, T. Hain, K. Schütze, U. Grundmann, V. Schmitt, M. Dorsch, J. Spanier, P. K. Larsen, T. S
Contacts and Locations
Paul Klein Center for Immune Intervention
Contacts:
Spokespersons of the FZI:
Prof. Dr. Tobias Bopp
Institut for Immunology of the University Medical Center of the Johannes Gutenberg-University Mainz
Prof. Dr. Stephan Grabbe
Director of the Department of Dermatology of the University Medical Center of the Johannes Gutenberg-University Mainz
Vice-Spokespersons of the FZI:
Prof. Dr. Hansjörg Schild
Institut für Immunologie der Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Prof. Dr. Frauke Zipp
Klinik und Poliklinik für Neurologie
UNIVERSITÄTSMEDIZIN
der Johannes Gutenberg Universität Mainz
Forschungszentrum für Immuntherapie (FZI)
Paul-Klein-Zentrum für Immunintervention
PKZI/Gebäude A, Raum
Langenbeckstr. 1
Mainz
Phone: +49 (0) 17
Fax: +49 (0) 17
University Medical Center (UMC) Mainz
Selected publications by Tobias Bopp
Johann K*, Bohn T*, Shahneh F*, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T#, Barz M#, Becker C#. Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression. Nat Commun 12(1) *Joint first authors, #corresponding authors Link
Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. Dec 19(12) Link
Ulges A*, Witsch EJ*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F, Bopp T. Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. Sep 6;(36) *joint first authors (open access) Link
Ulges A, Sc
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